In the current release of the Allen Cell Types Database, we include electrophysiological recordings from 1058 mouse cells and 279 human cells, a subset of which also include morphological reconstruction and Neuronal Models. The Cell Feature Search page allows you to find cells whose associated properties obtained from specimens that satisfy certain conditions. For example, you can choose to select only cells from a certain species and certain cortical layers. You can also use this page to find cells for which specific types of data are available. For example, you can choose to select only cells for which there is not only electrophysiological data, but also morphological reconstructions and neuronal models.
The Cell Feature Search page is divided into three areas: 1) In the top area, you can set filter filters for parameters for conditions that take discrete values, such as species and cortical layers. 2) In the middle area, you can set filters for numerical results in certain value ranges by using a Parallel Coordinate Plot. 3) In the bottom area, you see brief summary cards for the cells that were selected with the filters set in the two areas above, and you can choose the sorting order in which those cards are displayed.
The cell summary cards provide a link to a page displaying the available electrophysiological data (including possible neuronal models) and, if available, a link to a page displaying the available morphological data.
There are several methods to search this database; 1) enable specific by selecting from the "Filters" menu, 2) use the slider bars in the or 4) select from one of the curated Electrophysiological or Morphological searches.
To filter the neurons in your list of results, select from the mouse line, the cortical layer (1, 2/3, 4, 5, 6), and the Cell Reporter (Positive or Negative). By
Quick Electrophysiological or Morphological searches are available by clicking on those headings above the map.
Morphological Curated Search
A fraction of the cells that were selected for imaging and reconstruction (see Morphology Overview whitepaper in Documentation for more details) showed enough morphological similarities that a curated search based on these features is available from the Morphology link above the Cell Location map. To find similar cells based on Normalized Cortical Depth and Mouse Line, click on the average morphology thumbnail to pull up a list of cells that fit that criteria. Note: the number of cells that fit the criteria is listed in the title banner of the Filters box.
Electrophysiological Curated Search
A fraction of cells with well-characterized electrophysiological properties (see Electrophysiology Overview whitepaper in Documentation for more details) have been selected for a curated search and are available by clicking on the Electrophysiology link from above the Cell Location map. These searches select cell types with regular to moderate to fast spiking rates with unique adaptation or time constant parameters. To select the cells with these characteristics, click on the image. Note: the number of cells that fit the criteria is listed in the title banner of the Filters box.
Parallel Coordinate Plot of the Cell Features