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  1. Interrogate intrinsic membrane mechanisms that underlie the input/output function of neurons
    1. Linear and non-linear subthreshold properties A2.
    2. Action potential initiation and propagation A3.
    3. Afterhyperpolarization/afterdepolarization
  1. Understand aspects of neural response properties in vivo
    1. Stimulation frequency dependence (theta vs. gamma) of spike initiation mechanisms

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    1. Ion channel states due to different resting potentials in vivo

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  1. Construct and test computational models of varying complexity emulating the neural response to stereotyped stimuli

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        1. Generalized leaky-integrate-and-fire (GLIF) models

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        1. Biophysically and morphologically realistic conductance-based compartmental models

      Neuronal Models