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  1. Interrogate intrinsic membrane mechanisms that underlie the input/output function of neurons
    1. Linear and non-linear subthreshold properties
    2. Action potential initiation and propagation
    3. Afterhyperpolarization/afterdepolarization
  2. Understand aspects of neural response properties in vivo
    1. Stimulation frequency dependence (theta vs. gamma) of spike initiation mechanisms
    2. Ion channel states due to different resting potentials in vivo
  3. Construct and test computational models of varying complexity emulating the neural response to stereotyped stimuli
    1. Generalized leaky-integrate-and-fire (GLIF) models
    2. Biophysically and morphologically realistic conductance-based compartmental models


A1

A2

A3

B1

B2

C1

C2

Ramp

X

X

 

 

 

X

X

Long Square

X

X

 

 

 

 

X

Short Square

 

X

X

 

 

X

 

Short Square - Hold

 

X

 

 

X

 

 

Short Square - Triple








Noise (1 & 2)

 

 

 

X

 

X

 

Ramp to Rheobase




X


X


Square Suprathreshold



X




X

Square Subthreshold

X






X

Neuronal Models