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h1. Aging, Dementia and Traumatic Brain Injury Project

The Aging, Dementia and Traumatic Brain Injury Project is a detailed neuropathologic, molecular and transcriptomic characterization of brains of control and TBI exposure cases from a unique aged population-based cohort from the Adult Changes in Thought (ACT) study of aging and dementia. 

h2. KEY FEATURES:

[Overview: |aging:Overview] Curated visualizations of the data in this resource. 


!Overview.PNG|align=left!
* t-Distributed Stochastic Neighbor Embedding (t-SNE) plots paired with Parallel Coordinates plots designed to reduce the complexity of this high-dimensional dataset, allowing forcorrelations 2-D clustering of in the samples in data spaceto andbe explored
* NumerousSnapshots definedof neuronalgenetic populationsdata *organized Stacksby of two-dimensional images obtained by serial two-photon tomography
* [BDA vs. AAV|mouseconnectivity:BDA-AAV Comparison] for direct comparison of data derived from both conventional and viral tracing methodsgender, structure, cell-type, inflammation, dementia and TBI
* Snapshot of neuropathologic data paired with demographic data
* Interactive versions of each snapshot to allow for exploration of the data


{bgcolor:beige}h4. Additional Data in Adult Changes in Thought (ACT) Study and How to Access It

{bgcolor:beige}    _The Adult Changes in Thought (ACT) study is a longitudinal population-based prospective cohort study of brain aging and incident dementia in the Seattle metropolitan area. ACT is a Repository administered by the Group Health Research Institute (GHRI),  which has established policies and procedures for sharing data with external investigators. Data available from this project web site do not require any additional Institutional Review Board (IRB) approval or permissions. Linking those data with other ACT study or Group Health data would require additional review. All of those steps are initiated after contacting ACTproposals@ghc.org._{bgcolor}