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Property nameProperty description
SpeciesSpecies of recorded cell.
Cell idUnique cell identifier.
AreaBrain region of recorded cell.
LayerCortical layer of recorded cell.
Dendrite typeStatus of dendritic spines.
Cre lineTransgenic driver of reporter expression (mouse cells only).
Cell reporterExpression of transgenic reporter (mouse cells only).
DonorAge and sex of donor (human cells only).
Disease stateDisease state of donor (human cells only).
Short pulse thumbnail (red)Single action potential elicited by a short (3 ms) square current injection.
Long pulse thumbnail (blue)

Subthreshold, threshold, and suprathreshold responses to a sustained (1 s) square current injection.

Morphology thumbnail

The 2D projection of the neuron reconstruction shows dendrites in red, apical dendrite in orange and axon in blue.

The scale on the right represents the normalized cortical depth, from white matter to pia. The histogram shows the density of neuronal processes as a function of depth.

Electrophysiology linkLink to page displaying the electrophysiology experiment results and, when they are available, neuronal model simulations.
Morphology linkLike to page displaying morphological properties of the cell when they are available.

Electrophysiology details page

The electrophysiology details page starts with information about the cell and a list of cell features and plots of the V-I and F-I curvers.

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  1. Interrogate intrinsic membrane mechanisms that underlie the input/output function of neurons
    1. Linear and non-linear subthreshold properties
    2. Action potential initiation and propagation
    3. Afterhyperpolarization/afterdepolarization
  2. Understand aspects of neural response properties in vivo
    1. Stimulation frequency dependence (theta vs. gamma) of spike initiation mechanisms
    2. Ion channel states due to different resting potentials in vivo
  3. Construct and test computational models of varying complexity emulating the neural response to stereotyped stimuli
    1. Generalized leaky-integrate-and-fire (GLIF) models
    2. Biophysically and morphologically realistic conductance-based compartmental models

Neuronal Models

Warning

Reprocessing of the data occurred for the March 2016 release so any analysis performed prior to the March 2016 release date should be performed again with the new models.

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Model Name

Description

1. Leaky Integrate and Fire (LIF)

Standard circuit representation of a resistor and capacitor in parallel with a leaky membrane.

2. LIF + Reset Rules (LIF-R)

LIF with biologically-derived threshold and voltage reset rules in addition to a biologically derived threshold decay.

3. LIF + Afterspike Currents (LIF-ASC)

LIF with spike-induced currents to model long-term effects of voltage-activated ion channels.

4. LIF-R + Afterspike Currents (LIF-R-ASC)

LIF with additional Reset Rules and Afterspike Currents.

5. LIF-R-ASC + Threshold Adaptation (LIF-R-ASC-A)

All of the above, with an additional voltage-dependent component of threshold.

Biophysical-Perisomatic

Biophysically realistic, single-neuron model with passive dendrites and active soma.

Biophysical-All Active

Biophysically realistic, single-neuron model with active conductances everywhere.

Morphology details page

The Experimental Detail page includes the morphology summary and a viewer to browse the morphology data. The Morphology Summary includes the location of the cell mapped to the CCF, metadata on the Mouse Line and location of the cell. It also shows the Morphological features most appropriate to the data (see more information in the Morphology whitepaper in Documentation), a thumbnail showing the neuron reconstruction including cortical depth, as well as a thumbnail illustrating the electrophysiology traces.

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