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  1. Interrogate intrinsic membrane mechanisms that underlie the input/output function of neurons
    1. Linear and non-linear subthreshold properties
      A2. Action potential initiation and propagation
      A3. Afterhyperpolarization/afterdepolarization

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  • Understand aspects of neural response properties in vivo

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        • Stimulation frequency dependence (theta vs. gamma) of spike initiation mechanisms
          B2. Ion channel states due to different resting potentials in vivo

      C. Construct and test computational models of varying complexity emulating the neural response to stereotyped stimuli
      C1. Generalized leaky-integrate-and-fire (GLIF) models
      C2. Biophysically and morphologically realistic conductance-based compartmental models

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