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Aging, Dementia and Traumatic Brain Injury Project

The Aging, Dementia and Traumatic Brain Injury Project is a detailed neuropathologic, molecular and transcriptomic characterization of brains of control and TBI exposure cases from a unique aged population-based cohort from the Adult Changes in Thought (ACT) study of aging and dementia.

KEY FEATURES:

Overview Curated visualizations of the data in this resource.

  • t-Distributed Stochastic Neighbor Embedding (t-SNE) plots designed to reduce the complexity this high-dimensional dataset, allowing for 2-D clustering of the samples in data space and
  • Numerous defined neuronal populations
  • Stacks of two-dimensional images obtained by serial two-photon tomography
  • BDA vs. AAV for direct comparison of data derived from both conventional and viral tracing methods
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Additional Data in Adult Changes in Thought (ACT) Study and How to Access It

The Adult Changes in Thought (ACT) study is a longitudinal population-based prospective cohort study of brain aging and incident dementia in the Seattle metropolitan area. ACT is a Repository administered by the Group Health Research Institute (GHRI), which has established policies and procedures for sharing data with external investigators. Data available from this project web site do not require any additional Institutional Review Board (IRB) approval or permissions. Linking those data with other ACT study or Group Health data would require additional review. All of those steps are initiated after contacting ACTproposals@ghc.org.

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