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Aging, Dementia and Traumatic Brain Injury Project

The Aging, Dementia and Traumatic Brain Injury Project is a detailed neuropathologic, molecular and transcriptomic characterization of brains of control and TBI exposure cases from a unique aged population-based cohort from the Adult Changes in Thought (ACT) study of aging and dementia.

KEY FEATURES:

Overview: Curated visualizations of the data in this resource.

  • t-Distributed Stochastic Neighbor Embedding (t-SNE) plots paired with Parallel Coordinates plots designed to reduce the complexity of this high-dimensional dataset, allowing correlations in the data to be explored
  • Snapshots of genetic data organized by gender, structure, cell-type, inflammation, dementia and TBI
  • Snapshot of neuropathologic data paired with demographic data
  • Interactive versions of each snapshot to allow for exploration of the data
Specimens: Links to Donor Data
  • Matrix of donors sortable by demographic and neuropathologic metadata
  • Link to all metadata from an individual donor

[RNA Sequencing:]

  • Sequencing data to a depth of 2.4M reads
  • Heatmap representation sortable by metadata
  • Link specific genes in genome browser
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Additional Data in Adult Changes in Thought (ACT) Study and How to Access It

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The Adult Changes in Thought (ACT) study is a longitudinal population-based prospective cohort study of brain aging and incident dementia in the Seattle metropolitan area. ACT is a Repository administered by the Group Health Research Institute (GHRI), which has established policies and procedures for sharing data with external investigators. Data available from this project web site do not require any additional Institutional Review Board (IRB) approval or permissions. Linking those data with other ACT study or Group Health data would require additional review. All of those steps are initiated after contacting ACTproposals@ghc.org.

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