...
Aging,
...
Dementia
...
and
...
Traumatic
...
Brain
...
Injury
...
Project
...
The
...
Aging,
...
Dementia
...
and
...
Traumatic
...
Brain
...
Injury
...
Project
...
is
...
a
...
detailed
...
neuropathological,
...
molecular
...
and
...
transcriptomic
...
characterization
...
of
...
brains
...
of
...
control
...
and
...
TBI
...
exposure
...
cases
...
from
...
a
...
unique,
...
population-based
...
aged
...
cohort
...
from
...
the
...
Adult
...
Changes
...
in
...
Thought
...
(ACT)
...
study
...
of
...
aging
...
and
...
dementia.
...
KEY
...
FEATURES:
...
Overview: Curated visualizations of the data in this resource.
- t-Distributed Stochastic Neighbor Embedding (t-SNE)
...
- plots
...
- paired
...
- with
...
- Parallel
...
- Coordinates
...
- plots
...
- designed
...
- to
...
- reduce
...
- the
...
- complexity
...
- of
...
- this
...
- high-dimensional
...
- dataset,
...
- allowing
...
- relationships
...
- in
...
- the
...
- data
...
- to
...
- be
...
- explored
...
- Snapshots
...
- of
...
- gene
...
- expression
...
- data
...
- organized
...
- by
...
- gender,
...
- structure,
...
- cell-type,
...
- inflammation,
...
- dementia
...
- and
...
- TBI
...
- Snapshot
...
- of
...
- neuropathological
...
- data
...
- paired
...
- with
...
- demographic
...
- data
...
- Interactive
...
- versions
...
- of
...
- each
...
- snapshot
...
- to
...
- allow
...
- for
...
- exploration
...
- of
...
- the
...
- data
Specimens:
...
Links
...
to
...
Donor
...
Data
...
- Matrix
...
- of
...
- donors
...
- sortable
...
- by
...
- demographic
...
- and
...
- neuropathological
...
- metadata
...
- Link
...
- to
...
- all
...
- metadata
...
- and
...
- image
...
- data
...
- for
...
- each
...
- individual
...
- donor
RNA Sequencing:
- Differential and Correlation searches
- Heatmap representation sortable by metadata
- Link to genome browser for simultaneous sequence-level viewing of multiple samples
Download the data
- RNA-Seq data (raw data and normalized data matrix)
- Histopathological data and metadata
- Donor weights for making inferences that apply to the entire ACT Cohort
| Wiki Markup |
|---|
{bgcolor:beige}
h4. Additional Data in the ACT Study and How to Access It
{bgcolor:beige} _The ACT study is a longitudinal population-based prospective cohort study of brain aging and incident dementia in the Seattle metropolitan area. ACT is a Repository administered by the Group Health Research Institute (GHRI), which has established policies and procedures for sharing data with external investigators. Data available from this project web site do not require any additional Institutional Review Board (IRB) approval or permissions. Linking those data with other ACT study or Group Health data would require additional review which can be initiated by contacting ACTproposals@ghc.org._{bgcolor} |
Overview
Content Tools
ThemeBuilder