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Ivy Glioblastoma Studies

 

 

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Study

 

 

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Description

 

Anatomic Structures ISH SurveyPrimary screen of 8 tumors with probes for 343 genes enriched in glioblastoma.

Anatomic Structures RNA-SeqScreen of 5 structures (Leading Edge, Infiltrating Tumor, Cellular Tumor, Microvascular Proliferation, and Pseudopalisading Cells Around Necrosis) identified by H&E staining. A total of 122 RNA samples were generated from 10 tumors.

Anatomic Structures ISH for Enriched GenesSubsequent screen of 29 tumors with probes for 37 genes enriched in glioblastoma structures identified in Anatomic Structures RNA-Seq Study.

Cancer Stem Cells ISH SurveyPrimary screen of 16 tumors with probes for 55 genes enriched in putative cancer stem cells, resulting in a 20 probe reference set, which was then used in an extensive screen of 42 tumors.

Cancer Stem Cells RNA-SeqScreen of 35 clusters of putative cancer stem cells identified by ISH with a 17 reference probe subset (validated in the Cancer Stem Cells ISH Survey). A total of 148 RNA samples were generated from 34 tumors.

Cancer Stem Cells ISH for Enriched GenesSubsequent screen of 37 tumors with probes for 76 genes enriched in clusters of putative cancer stem cells identified in the Cancer Stem Cells RNA-Seq Study.

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