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Operator

Example Search Type

Example Query

AND operator: &

Gene

dopamine & receptor

OR operator: |

Gene

"ABAT\

NOT operator: !

Gene

"dopamine receptor" !DRD3

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Another common usage of gene expression databases is to find genes that show enrichment of expression in one region compared to another region. This type of query is supported by the "Differential Search" mode. Select the "Differential Search" radio button. To find genes or probes with a higher expression in one structure when compared to another structure, enter the target brain structure in the top search box and your contrast region in the bottom search box and click on the Search button.

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Your search will return results in the two brain regions selected. The results will show higher expression in the target region compared to the contrast region. (To view the expression patterns of the returned probes over the entire brain, turn off the "Restrict Domains" function below the heat map.) Search results are sorted either by p-value or fold change, indicated by the arrow on the buttons over the column of genes. To alter the sort parameter, click on either the "p value" or the "fold-change" buttons.

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To perform the previous search in reverse, click the toggle button beside the Search button.

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