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- Pipe1: Set up contrast structure list by finding structure cerebral cortex in the Human Brain ontology
- Pipe2: Set up target structure list by finding structure thalamus in the Human Brain ontology
- Connect the two pipes toservice::human_microarray_differentialto perform the differential search
- Visualize the same search result in the Web application
Figure: Screenshot of top returns of a differential search for genes with higher expression in the thalamus than the cerebral cortex. Z-score heatmap shows enrichment (red) in the thalamus (structure color: light green) compare to other brain regions.
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- Pipe1: Set up the seed probe by finding PVALB probe CUST_11451_PI416261804
- Pipe2: Set up the domain structure list by finding structure Brain in the Human Brain ontology
- Connect the two pipes toservice::human_microarray_correlationto perform the correlation search
- Visualize the same search result in the Web application
Figure: Screenshot of top returns of a correlative search for probes with similar expression to a PVALB probe with expression values displayed as a z-score heatmap.
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T1-weighted MPRAGE scans were acquired the postmortem brains using 3T Siemens Trio MR scanners (TI=900ms, TR=1900ms, TE=3.03ms, 9 degree flip angle, 1mm isotropic voxels). Scans were performed in cranio for some brains and ex cranio for others. See the white papers for more specific scan sequence details for each brain.
Figure: T1 MR scan for donor 'H0351.2002'
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