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Brain Atlas



Image Added The Allen Human Brain Atlas is an online a multimodal atlas of the human brain that integrates anatomic and microarray-based gene expression information. Microarray sampling sites (~400-1000 sites per brain) were identified by expert anatomists using cytoarchitectural information from multiple histological stains. Sampling site delineations in the high resolution histological images were subsequently mapped into each individual's MR image space to provide 3-D anatomical context. All brains are also registered to MNI space to enable cross-individual comparisons.

Online and desktop interactive tools were developed to navigate and visualize the data. All expression values and images are available through the Allen Institute API.

http://iwarehouse/doc/index.htmlFrom the API, you can:

Microarray Data

RNA isolated from each sample area was hybridized to a custom Agilent 8x60k microarray chip to measure gene expression over the transcriptome. All least two different probes were available for 93% of genes. Probes were located on different exons as much as possible when multiple probes were available for a gene. For 60 genes, a set of tiling probes were probes was designed.