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Usage of this service is demonstrated in the SPM example application.

Correlative search

Correlative search finds probes with similar expression profile to the selected seed probe over all samples within a user-specified structure. Pearson's correlation coefficient is computed for all probes and results ranked in descending order.

Image Added This correlative search function can be access through the Web application or using the RMA Services and PipesAPI.

See the connected service page for definitions of service::human_microarray_correlation parameters.

Example:
Correlative search for probes with similar expression to PVALB probe CUST_11451_PI416261804 over the whole brain

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Brain

• Find Probe ID for probe "CUST_11451_PI416261804
• Pipe2: Set up the domain structure list by finding structure Brain in the Human Brain ontology
• Connect the two pipes toservice::human_microarray_correlationto perform the correlation search" (id = 1052410)

  Code Block
  http://api.brain-map.org/api/v2/data/query.xml?criteria=model::Probe, rma::criteria,[name$eq'CUST_11451_PI416261804'], rma::options[only$eq'probes.id']

• Find Structure ID for "Brain" (id = 4005)

  Code Block
  http://api.brain-map.org/api/v2/data/query.xml?criteria=model::Structure, rma::criteria,[name$il'brain'],ontology[name$eq'Human Brain Atlas'], rma::options[only$eq'structures.id']

• Use Probe and Structure IDs as parameters to the connected service

  Code Block
  http://api.brain-map.org/api/v2/data/query.xml?criteria= service::dev_human_microarray_correlation[probes$eq1052410[structures$eq4005]

• Visualize the same search result in the Web application Image Removed

Figure: Screenshot of top returns of a correlative search for probes with similar expression to a PVALB probe with expression values displayed as a z-score heatmap.http://iwarehouse/doc/index.html

Magnetic Resonance Imaging

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