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SearchServices
SearchServices
Projection Grid Search Service

Image Removed The A projection grid search service is available through both the Web application and API.service has been implemented to allow users to instantly search over the whole dataset to find experiments with specific projection profiles.

  • The Source Search function retrieves experiments by anatomical location of the injection site.
  • The Target Search function returns a rank list of experiments by signal volume in the user specified structure(s).
  • The Spatial Search function returns a rank list of experiments by density of signal in the user specified voxel location.
  • The Injection Coordinate Search function returns a rank list of experiments by distance of their injection site to a user-specified reference space coordinate.
  • The Correlation Search function enables the user to find experiments that have a similar spatial projection profile to a seed experiment when compared over a user-specified domain

Image Added The projection grid search service is available through both the Web application and API.

Source Search

To perform a Source Search, a user specifies a set of source structures. The service returns all experiments for which either the primary injection structure or one of its secondary injection structures corresponding to one of the specified source structures or their descendents in the ontology. The search results can also be filtered by a specified list of transgenic lines.

Example: Source search for experiments with injection in the isocortex

Example: Source search for experiments performed on wild-type specimens and injection in the isocortex

Example: Source search for experiments performed on Syt6-Cre_KI148 cre-line with injection in the isocortex

Figure: Screenshot of source search results in the web application for experiments with injection in the isocortex. The injection location of each experiment is shown as a sphere on the 3D injection map.

Target Search

To perform a  Target Search, the user specifies a set of target structures. The service returns a rank list of experiments by signal volume in the target structures which are above a minimum threshold. The target structure specification can be further refined by hemisphere. The search results can also be filtered by a list of source structures and/or list of transgenic lines.

Example: Target search for experiments with projection signal in the target structure LGd (dorsal part of the lateral geniculate complex) and injection in the isocortex

Figure: Screenshot of source search results in the web application for experiments with projection in target structure LGd (dorsal part of the lateral geniculate complex) and injection in the isocortex. The injection location of each experiment is shown as a sphere on the 3D injection map.

Spatial Search

To perform a Spatial Search, a user selects a target location within the 3D reference space. The service returns a rank list of experiments by signal density in the target location and with density greater than 0.1. The search results can also be filtered by a list of source structures and/or list of transgenic lines.

Example: Spatial search for experiments with projection signal in a target location in VM (ventral medial nucleus of the thalamus) and injection in the isocortex

Figure: Screenshot of spatial search results in the web application for experiments with projection in target location within VM (ventral medial nucleus of the thalamus) and injection in the isocortex. Each line in the 3D map is the computationally generated path from the target location to injection of one experiment.

Injection Coordinate Search

To perform an  Injection Coordinate Search, a user specifies a source location within the 3D reference space. The service returns a rank list of experiments by distance of its injection to the specified source location. The search results can also be filtered by a list of source structures and/or list of transgenic lines.

 Example: Injection coordinate search for experiments with a source location in VM

Correlation Search

To perform a Correlation Search, the user selects a seed experiment and a domain over which the similarity comparison is to be made. All voxels belonging to any of the domain structures form the domain voxel set. Pearson's correlation coefficient is computed between the domain voxel set from the seed experiment and every other experiment in the product. The return list is sorted by descending correlation coefficient.

 Example: correlation with seed experiment 112670853