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Color Key | Study | Description |
|---|---|---|
| Anatomic Structures ISH Survey | Initial Primary screen of 8 tumors with probes to 344 glioblastoma-enriched genes for 343 genes enriched in glioblastoma |
| Anatomic Structures RNA-Seq | Screen of 5 structures (Leading Edge, Infiltrating Tumor, Cellular Tumor, Microvascular Proliferation, and Pseudopalisading Cells Around Necrosis) identified by H&E staining in . A total of 122 RNA samples were generated from 10 tumors. |
| Anatomic Structures ISH for Enriched Genes | Final Subsequent screen of 29 tumors with 38 probes to for 37 genes enriched in particular anatomic glioblastoma structures as identified in Anatomic Structures RNA-Seq study Study |
| Cancer Stem Cells ISH Survey | Initial Primary screen of 16 tumors with 61 probes to 56 probes for 55 genes enriched in putative cancer stem cell-enriched genes to identify cells, resulting in a 20 probe reference set, which was then used in an extensive screen of 41 42 tumors |
| Cancer Stem Cells RNA-Seq | Screen of 35 types clusters of putative cancer stem cell clusters cells identified by ISH with a 17 reference probe reference set in subset (validated in the Cancer Stem Cells ISH Survey). A total of 148 RNA samples were generated from 34 tumors |
| Cancer Stem Cells ISH for Enriched Genes | Final Subsequent screen of 37 tumors with 77 probes to for 76 genes enriched in clusters of putative cancer stem cell clusters as cells identified in the Cancer Stem Cells RNA-Seq study Study |
KEY FEATURES:
In Situ Hybridization (ISH): Cellular resolution gene expression image data with adjacent hematoxylin and eosin (H&E)-stained sections that have been manually annotated for anatomic structures.
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