Aging, Dementia and Traumatic Brain Injury Project

The Aging, Dementia and Traumatic Brain Injury Project is a detailed neuropathological, molecular and transcriptomic characterization of brains of control and TBI exposure cases from a unique, population-based aged cohort from the Adult Changes in Thought (ACT) study of aging and dementia.


Overview: Curated visualizations of the data in this resource.

Specimens: Links to Donor Data

RNA Sequencing:

Download the data


Additional Data in the ACT Study and How to Access It

The ACT study is a longitudinal population-based prospective cohort study of brain aging and incident dementia in the Seattle metropolitan area. ACT is a Repository administered by Kaiser Permanente Washington Health Research Institute (formerly the Group Health Research Institute), which has established policies and procedures for sharing data with external investigators. Data available from this project web site do not require any additional Institutional Review Board (IRB) approval or permissions. Linking those data with other ACT study or Kaiser Permanente Washington data would require additional review which can be initiated by contacting